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Importantly, microglia in this activated state also secrete pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which further amplify ROS production and reinforce the inflammatory state
"An Update on Glutathione's Biosynthesis, Metabolism, Functions, and Medicinal Purposes." Curr Med Chem
Science 347 , 1260419 (2015)
Bringing any drug through Phase II and Phase III to regulatory approval costs hundreds of millions
Furthermore, Bim, the downstream mediator of JNK, shows dual effects on autophagy and apoptosis (116, 228)
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