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However, in recent years, it has come to light that these drugs can be very effective for weight loss

This is a bit like blaming the shoes for getting tired after walking 3 hours uphill

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However, its C-terminal end can be cleaved by carboxypeptidase A, and removal of the last leucine residue (L585) weakens receptor binding, reducing its half-life from 20 days to 3.5 days in humans

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