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Studies comparing delivery methods show topical formulations achieve only a fraction of the bioavailability that subcutaneous injection provides

M.SagiI.HubermanM.MelamedE.KorczynA.GiladiN.et al (2000)

In people with type 2 diabetes, the combination showed a clinically relevant improvement in CGM profiles, with an impressive almost 90% [time in range] at 32 weeks, Mathieu said

The same compound delivered topically through a serum, applied with microneedling, injected directly into the scalp, or injected subcutaneously into the abdomen will produce very different biological effects

But that is where the similarities end

then 800 mcg/day, Weeks 34