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Importantly, although their glucose-lowering efficacy diminishes in advanced CKD, cardiovascular and kidney benefits remain preserved [111]

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Milk thistle has been shown in experimental animal studies to stimulate bone mineralization and potentially be protective against bone loss

GLP-1 medications have generally been well-tolerated for long-term use, though they may have mild to moderate side effects such as nausea, vomiting, diarrhea, abdominal discomfort, or occasional constipation

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