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To evaluate whether GLP-1R and PKA signalling participated in the protective effect of metformin in HUVECs, siRNAs as well as pharmacological blocking were introduced in our study

Ong, Q., Guo, S., Zhang, K

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performed a metanalysis comparing the extraglycaemic effects of various antihyperglycaemic agents on the lipid profile in type 2 diabetes (34)

To provide a more accurate prediction of skin irritancy potential of the test compound, in vitro skin irritation test can include other potential biomarkers