Research on the compound indicates it stimulates the former while inhibiting the latter, acting locally on adipose tissue in a manner that mirrors the fat-metabolizing region of full-length growth hormone without activating the receptor pathway responsible for growth and blood sugar effects
These differences in duration can impact convenience, side effects, and how the medication fits into a broader weight management plan
Last reviewed: May 22, 2026 Last updated: May 22, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
Lets break it down: The Science Stuff (Simplified) Semaglutide mimics one hormone (GLP-1) Tirzepatide mimics two (GLP-1 + GIP) Both help regulate appetite, insulin, and blood sugar They're available as injectables , and in some programs including Josie you may be offered compounded oral tablets if appropriate
All from the comfort of home
It is only available through compounding pharmacies or as a research peptide