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Some people tolerate small amounts without issue, while others experience significant nausea or other side effects even with modest consumption
So we have to keep that in mind when we're considering what we're starting to see in these trials
SGLT2 inhibitors , such as canagliflozin, work by preventing the kidneys from reabsorbing glucose, thus increasing glucose excretion in the urine
It promotes arterial vasodilation by binding GLP-1R in endothelial cells and releasing NO [69]
In type 2 diabetes, the primary therapeutic objective is to reduce blood glucose levels and lower HbA1c
So if you have an intestinal obstruction, the drug may worsen it
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