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10.3390/healthcare2040429 112 NelsonK
Over the last 5 years, with the emergence of newer agents including sodium-glucose cotransporter-2 (SGLT2) inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1 RA) and novel mineralocorticoid receptor antagonist (MRA), management of type 2 diabetes mellitus (T2DM) and DKD has since shifted away from a glucose-centric focus towards one of heart and kidney protection [35]
As extensive as these metabolic changes were, and although they possess concordance with the functional and vascular changes previously demonstrated in our lab, they must be acknowledged to be preliminary and limited in their failure to display the full profile of ischemic myocardial GLP-1 agonism
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