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gingivalis , a predominant periodontal pathogen, has been detected in the hippocampal and cortical regions of AD patients, correlating with classic AD-like pathology such as neuroinflammation, neurodegeneration, tau phosphorylation, and the formation of both intracellular and extracellular A plaques and neurofibrillary tangles
Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models